In this study, we focused on the spatial characteristics of the DMN in acutely ill patients, and carried out an exploratory analysis of its temporal features as well. We used ICA to identify the DMN component in bipolar disorder patients with acute mania, schizophrenia patients with acute psychosis, and matched healthy control subjects. We first compared the spatial extent of the DMN across groups. Significant differences in this analysis correspond to differences in the correlation of BOLD signal with that of the DMN, which does not necessarily reflect differences in activity level. Next, we used Fourier transformations of BOLD signal timecourse and compared oscillation frequency within the DMN across groups. To control for generalized abnormalities in resting-state activity, we carried out a parallel analysis on the primary visual cortex (V1) component. We reasoned that focusing on acute psychopathology would reveal both shared and distinct abnormalities in the DMN with those reported in stable outpatients. Psychopathology is chronic and unrelenting in schizophrenia so we hypothesized loss of medial PFC coherence with the DMN as previously reported in stable outpatients (Whitfield-Gabrieli et
