both shared and distinct abnormalities in the DMN with those reported in stable outpatients. Psychopathology is chronic and unrelenting in schizophrenia so we hypothesized loss of medial PFC coherence with the DMN as previously reported in stable outpatients (Whitfield-Gabrieli et al., 2009; Camchong et al., 2009; Calhoun et al., 2007; Garrity et al., 2007; Bluhm et al., 2007). On the other hand, we predicted that acutely manic subjects would show loss of PFC coherence with DMN, although studies of stable outpatients with bipolar disorder have not reported this. We also predicted that both patient groups would show abnormalities in the frequency of BOLD signal fluctuation within the DMN reflecting dysregulation of cortical activity during acute illness.
