The aim of this study was to investigate the relationship between the rate of adolescent nicotine metabolism and the components of cigarette puffing patterns recorded during a smoking topography session among adolescent dependent smokers. In addition, because sex differences have been shown in some topography measures [16, 17], and because nicotine metabolism may differ by sex and hormonal contraceptive (HC) use [18, 19] and ethnicity [20], we examined the same relationships in stratified subsets of our overall sample.
