We use three independent external data sets for replication (Supplementary Note). First, for the GWAS analysis based on advanced 1000G imputation enhanced by UK10K data we consider SNVs with MAF ≥ 1% and perform a reciprocal replication exchange with the International Consortium of Blood Pressure (ICBP) 1000G meta-analysis (max N = 150,134). The imputation strategy for ICBP 1000G meta-analysis is based on an earlier imputation grid for the 1000G project. In addition, we recruit further cohorts with 1000G data which had not contributed to the ICBP-1000G discovery meta-analysis: ASCOT-UK (N = 3,803), ASCOT-SC (N = 2,462), BRIGHT (N = 1,791), Generation Scotland (GS) (N = 9,749), EGCUT (N = 5,468), Lifelines (N = 13,292) and PREVEND (N = 3,619). This gives a total of N = 190,318 independent replication samples for the GWAS analysis.
