Overall, many other mutants, KI, KO, and transgenic mice of various GABA subunit genes have convincingly established a role for GABA in mediating the behavioral consequences of alcohol79 and other drugs.83 The specific genes and alleles may differ from those associated in humans, but overall, animal models have confirmed and extended findings of GABA's involvement in AD and other addictions.79,83 The molecular mechanism of the effects of GABA are being established by microarray analysis.79,84
