number of cigarettes smoked (rg = 0.45, P = 1.07 × 10−5) are reinforced by significant positive correlation with lung cancer (rg = 0.39, P= 6.35 × 10−10). Similarly, genetic correlations related to obesity include significant relationships with body mass index (BMI; rg = 0.26, P = 1.68 × 10−15), waist-to-hip ratio (rg = 0.30, P= 1.16 × 10−17), childhood obesity (rg = 0.22, P = 3.29 × 10−6), HDL cholesterol (rg = −0.22, P = 2.44 × 10−7), and Type 2 Diabetes (rg = 0.18, P = 7.80 × 10−5). Additionally the negative correlation with years of schooling (rg = −0.53, P = 6.02 × 10−80) is supported by a negative genetic correlation with human intelligence (rg = −0.41, P = 7.03 × 10−26). Finally the genetic correlation with reproduction include a negative correlation with age of first birth (rg = −0.612, P = 3.70 × 10−61) and a positive correlation with number of children ever born (rg = 0.42, P = 8.51 × 10−17).
