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Chunk #15 — Results — Biological annotation of significant loci

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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.
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For the 12 genome-wide significant loci, Bayesian credible sets were defined to identify the set of variants at each locus most likely to include a variant with causal effect (Online Methods, Supplementary Data 2; Supplementary Table 6). Biological annotations of the variants in the credible set were then considered to identify functional or regulatory variants, common chromatin marks, and variants associated with gene expression (eQTLs) or in regions with gene interactions observed in Hi-C data (Online Methods, Supplementary Data 3). Broadly, the significant loci do not coincide with candidate genes proposed to play a role in ADHD62.