the 16q.12.2 locus (Fig. 4), which further supports the hypothesis that these genes are involved in the risk of BMI. Of the 48 loci that contained at least one prioritized gene from positional and eQTL mappings, chromatin interaction mapping identified candidate genes in additional 18 loci (Supplementary Fig. 2), including loci mapped to known genes associated with BMI such as MC4R, FOXO3, and ADCY9. The 400 prioritized genes showed enrichment in 9 GO terms, such as “response to zinc ion” and “oligopeptide binding” overlapping with multiple metallothionein and glutathione S-Transferase genes whose association with obesity risk has been reported45,46 (Supplementary Data 6).Table 2Summary of FUMA application to three GWAS summary statisticsGWASRisk lociReported genes in the original studyPositional mappingeQTL mappingChromatin interaction mappingTotal* Genes located outside the risk lociNovel candidatesLoci contain prioritized genesBMI771172314431040026326367CD71115396919927616121555SCZ109349365433113263545*The number of unique genes mapped by one of the positional, eQTL and chromatin interaction mappings
