We then performed chromatin interaction mapping using Hi-C data of 14 tissue types (Methods). FUMA prioritized 310 genes (Supplementary Data 4), of which 61 genes are overlapping with the genes prioritized by positional and/or eQTL mappings and 232 genes are located outside of the genomic risk loci (Fig. 2). That resulted in a total of 400 prioritized genes by combining three mapping strategies including 330 novel candidates which were not reported in the original study (Table 2 and Supplementary Data 4). These novel candidates further supported shared biological functions with previously reported known genes, such as lipid and lipoprotein metabolism, homeostatic process and various metabolic pathways, with a greater number of genes compared to the mappings without Hi-C data (Supplementary Data 5). Out of 400 prioritized genes, 59 genes are mapped by both eQTLs and chromatin interactions including IRX3 on the 16q.12.2 locus (Fig. 4), which further supports the hypothesis that these genes are involved in the risk of BMI. Of the 48 loci that contained at least one prioritized gene from positional and eQTL mappings, chromatin interaction mapping identified
