none of the associated SNPs have a potential direct affect such as coding SNPs on FTO. Two of the genes prioritized by FUMA (RBL2 and IRX3) are physically located outside the genomic locus and are missed when using conventional approaches that prioritize genes located in the locus of interest based on LD around the top SNP. Although the IRX3 gene was not reported in the original study43, recent functional work has indeed validated this as the causal gene whose expression is affected by SNPs in the 16q.12.2 locus44.
