The future is certainly going to have many ways to study organs in correct context. Whether we call these 3D cultures or organoids is like calling a rose by any other name. What we should keep in mind is that the essence is the same. The field has arrived and scientists now appreciate that “dimensionality” and context hugely matter. This field and this way of thinking will remain central in the development of new therapeutic strategies and in the advancement of personalized medicine. In studying 3D cultures and organoids, revisiting the past allows us to understand where we should be going.