In the current study, we examined associations between childhood trauma, APOEε4, and measures of brain functioning (i.e., neural connectivity) across adolescence and young adulthood (ages 12–32) stratified by sex, as well as interactions between trauma exposure and APOEε4 on neural functioning. We also examined associations between differences in neural connectivity with downstream psychiatric (AUD and PTSD symptoms) and cognitive outcomes in young adulthood. We used data from the Collaborative Study on the Genetics of Alcoholism (COGA), a multi-site study of extended families densely affected with alcohol problems. Given our emphasis on associations between trauma, genetic risk, and neural functioning in adolescence, we focused specifically on the COGA prospective sample, comprising the adolescent and young adult offspring of the original COGA family sample. We hypothesized that childhood trauma and APOEε4 would be associated with differences in frontal alpha EEGc, with the most robust effects observed for individuals with childhood sexual assaultive trauma, a greater dementia risk and an APOEε4 dose. We further hypothesize that changes in neural connectivity associated with childhood trauma will associate with greater PTSD and AUD symptoms and
