Of the remaining SNPs nominally associated with HOD at p<.0001, two intronic SNPs in the ANKS1A gene were associated with HOD, AUD-FS, AD-FS and with AD diagnosis in CPC comparisons (rs1737727: p=5.5E-5, 7.4E-6, 6.6E-6 and 3.4E-4 respectively; rs 2140418: p=4.4E-5, 4.3E-6, 4.1E-6 and 1.6E-4) (see Table S9 in the Supplement); with the former also associated with heaviest period weekly consumption (p=6.3E-4), frequency of heavy drinking (p=3.2E-4) and MaxDrinks (p=4.6E-3). Neither were associated with AD diagnosis in family-based analyses. Additional ANKS1A SNPs show association with AUD-FS at p<0.0001 as well as with HOD at p<.005 (rs847851, rs847848, rs2273006 – the latter a TAF11 SNP but in complete LD with an ANKS1A SNP). An intronic SNP in CNGB3 (rs4961216) was associated with HOD (p=2.8E-5), AUD-FS (p=2.4E-4), binary AD in family-based analyses (p=3.0E-4) and AD in CPC comparisons (p=1.3E-4). Additional SNPs in USH2A, ITIH5, SHANK2 and C15orf32 showed nominal association with HOD, modest association with AUD-FS, but without confirmatory association with AD diagnosis (see Table S9 in the Supplement), as did a number of non-genic SNPs. Overall, 22 of 64 SNPs nominally associated
