SNPs showing strongest association with HOD and AUD-FS measures are summarized in Tables S5 and S6 in the Supplement. Additional Tables S7 and S8 in the Supplement show AD-FS and 12-month weekly consumption results. The small number of SNPs showing convergent evidence across phenotypes (at nominal p<.0001, for the primary phenotype and p<.005 for the confirmatory phenotype) are shown in Table S9 in the Supplement. A chromosome 3 SNP, rs2369955, that was the 3rd most highly associated SNP for HOD (p=1.6E-6) also showed associations with AUD-FS (p=1.3E-4), AD-FS (p=7.3E-5) heaviest period Frequency of Heavy Drinking (p=4.7E-6), Frequency Drunk (p=3.9E-5), Frequency of Any Use (p=4.9E-5) and with Weekly Alcohol Consumption (p=2.7E-5) measures; and was modestly associated with DSM-IV alcohol dependence diagnosis (p=1.5E-3). This SNP is intergenic but in moderate linkage disequilibrium with an intronic SNP in TMEM108 (rs10935045, bp 134282836: r2=0.49, D′=.73) that is the 4th most highly associated SNP for HOD factor score (p=1.7E-6) and also weakly associated with AUD-FS (p=6.4E-4). Both SNPs were only weakly associated with AD diagnosis in case-population control (CPC) comparisons (OR=1.18, 95% CI 1.02–1.37, p=.02; OR=1.17, 95% CI 1.02–1.31, p=0.03).
