Chunk #16 — Discussion

Source

Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.

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corroborate the role of nicotinic receptors in cocaine-related phenotypes. This study represents one of only a few to implicate specific variants in cocaine dependence phenotypes and the first to implicate low frequency variants within the CHRNB3-A6 locus in risk for DSM-5 cocaine use disorder.