tests (i.e., .05/42 = .001). Of particular note, the SNP in the autism susceptibility candidate 2 gene (AUTS2) on 7q11.22 identified as being significantly associated with alcohol consumption in a sample of more than 45,000 individuals, rs6943555, (Schumann et al., 2011) was not associated with either our Alcohol Consumption (p=.54) or Alcohol Dependence (p=.35) variables in our sample. Similarly, the SNPs in the nicotinic receptor gene cluster on 15q25.1 that have been associated with number of cigarettes smoked per day in 75,853 current smokers in the Tobacco and Genetics Consortium (rs1051730 and rs16969968) (Furberg et al., 2010) were not associated with our Nicotine composite variable (p > .40), although in measuring nicotine-related behavioral disinhibition we included both smokers and non-smokers in our analysis. Furberg et al. (2010) did not find association for rs1051730 and rs16969968 with ‘smoking initiation’ in their full sample of over 140,000 smokers and non-smokers. That said, we ultimately found no evidence of association of these 42 SNPs identified in previous relevant GWAS with any of our five phenotypes.
