We identified 51 SNPs associated in published GWAS at p < 5 × 10-7 with phenotypes related to behavioral disinhibition (including substance use and abuse, conduct disorder, and attention deficit/hyperactivity disorder) from A Catalog of Published Genome-Wide Association Studies (genome.gov, accessed January, 2012). Of these 51 SNPs, 16 had been genotyped on the Illumina 660W array and an additional 26 had been imputed with an r2 ≥ .50 using HapMap2 (mean = .977, range = .917 to 1.00). The remaining 9, which could not be imputed at r2 ≥ .50, are not analyzed here. The smallest p value for the association of any of these 42 SNPs with any of the five clinical phenotypes was .012 (full results summarized in Supplemental Table 5), which is an order of magnitude greater (i.e., less significant) than the Bonferroni corrected threshold for 42 tests (i.e., .05/42 = .001). Of particular note, the SNP in the autism susceptibility candidate 2 gene (AUTS2) on 7q11.22 identified as being significantly associated with alcohol consumption in a sample of more than 45,000 individuals, rs6943555, (Schumann et al.,
