showed a similar pattern of interaction that was consistent across the 5 phenotypes; namely that the SNP effect differed in direction between the parent and offspring generation. This is not unexpected, as the test statistic will be maximized when the observed direction of effect is not the same in the two generations, even when the null hypothesis is true. Two of the 4 SNPs are intergenic, and only one mapped near a gene that has been implicated in a behavioral study. The marker rs7968335 is approximately 30K bases downstream of SLC6A15, which has been associated with depression in a previous GWAS (Kohli et al., 2011).
