Our aim is to quantitatively demonstrate that disulfiram treatment is more effective in open-label rather than in blinded experiments, because in the later the psychological effect of the fear of a DER would be expected to have the same effect in both arms of the study. In addition, we expect that this analysis will show disulfiram to be more effective in supervised studies compared to unsupervised studies. Compliance has been a serious impediment in disulfiram research in numerous studies [26], [27].
