The previously published GWAS of OD19 and CD20 in a subset of this sample each identified risk genes and pathways involved in the regulation of neuronal calcium and potassium, and the pathway involving synaptic long-term potentiation was also identified for OD. Also, a cross-disorder analysis identified calcium signaling in neurons as a pathway mediating 5 psychiatric diseases, including SCZ and MDD.34 The GWS association in SLC35G1 and GWS (in the discovery sample only) associations in and around S100B suggest ion homeostasis may play a role in CAD risk.
