Transplantation of cholinergic precursors differentiated from iPSCs into AD transgenic mice proved to restore spatial memory impairment and survival of the cells transplanted (Fujiwara et al., 2013). A particular study reported that medial ganglionic eminence-like progenitors obtained from iPSCs differentiation, completed their maturation into the forebrain as GABAergic interneuron subtypes with mature physiological properties within a prolonged period of time that extended until 7 months, thus mimicking endogenous human neural development (Nicholas et al., 2013).
