This neurodegenerative disease is under extensive study for therapeutic options including cell-replacement based therapy. The need for urgent therapy stems from the fact that a small percentage of all AD patients get moderate improvement from all available AD drugs and a significant number of those patients suffer major side effects (Serretti et al., 2007). It is consistent that in AD animal models, there is decrease in neurogenesis in the subventricular and subgranular zones that get initiated early before Aβ plaque formation suggesting decreased neurogenesis and progressive neuronal loss as pathologies of AD (Yang et al., 2016).
