Alzheimer's disease (AD) is the most common form of age-related dementia (Alzheimer's Association, 2010), characterized by progressive cognitive disturbance and loss of memory. It is famously distinguished by the presence of two major hallmarks: extracellular accumulation of amyloid beta (Aβ) plaques and intracellular aggregation of the microtubule associated protein, tau. AD exists in as little as 1–5% in its familial form, characterized by autosomal dominant inheritance of Presenilin-1 or -2 or/and Amyloid Precursor Protein (APP), while the majority of AD cases to date are sporadic and multifactorial with suspected role of epigenetics involved in the course of progression. List of suspected genes include MAPT, BACE1, BACE2, ADAM10, ADAM17, and others (Karch and Goate, 2015).
