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Chunk #21 — DISCUSSION

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Gender differences in lifetime alcohol dependence: results from the national epidemiologic survey on alcohol and related conditions.
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as found in this study and others (Dawson and Grant, 1998). Individuals with a family history of alcohol use disorders are at greater risk of manifesting externalizing disorders (Hill et al., 2008). Conduct disorder in particular has been consistently associated with AD (Heath et al., 1997; Slutske et al., 1998) and may more strongly influence the risk of AD in women than in men (Heath et al., 1997; Slutske et al., 1998). Shared genetic factors account for much of the association between conduct disorder and adult AD, and there is evidence that these genetic factors may influence the heritability of these disorders more strongly in women (Slutske et al., 1998). Individuals with conduct disorder may be more likely to exhibit other externalizing disorders because of a genetic vulnerability to substance use disorders (Slutske et al., 1998), and because of a tendency to participate in environments that promote substance use.