We performed in-silico gene-based and transcriptome-based analyses (Tables S15–30), which consistently revealed both convergent and divergent associations for Consumption and Problems (Table S31). For example, both factors robustly implicated ethanol metabolizing genes (ADH1B, ADH1C) and dopamine transmission [DRD2, involved in mediating the rewarding effects of drugs (34)], as well as pleiotropic genes previously implicated in anthropometric and metabolic traits [e.g., CELF1 (5, 35)], and intelligence [e.g., MTCH2 (36), FAM180B/NDUFS3 (37)].
