and right insula response to reward anticipation loses some significance when controlling for family history and age (p=.07), whereas the remainder of the findings remain significant (p<.05). However, children of alcoholics (COA) showed greater activation of right insula to reward (p=.022) and loss (p=.038). By regressing out each SNP we confirm that they are not independent. For both SNPs we observed that A homozygotes and heterozygotes have similar means and, because of the small sample size in the fMRI study, grouped them together and compared them to GG mean values.
