Chunk #8 — Materials and Methods — Marker selection, genotyping and error checking

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Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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Eight markers across the 45kb region in CNR1 were selected (Figure 1). From 5’ to 3’ of CNR1, the 8 markers were numbered as SNPs 3–10 [matching their designation in our initial study (Zuo et al 2007)]. They were selected from the NCBI dbSNP database or from the Applied Biosystems SNP database. Marker selection was based on published data, minor allele frequency, information content, LD structure, region coverage, and potential function.