PA significantly (betainteraction = −0.14 kg/m2 per allele, p interaction = 0.005) attenuated the association between the FTO variant and BMI in our meta-analysis of 218,166 adults (Figure 2; Table 2) (i.e., a betainteraction of −0.14 kg/m2 represents the difference in the BMI-increasing effect of the risk allele between physically active and inactive individuals). The magnitude of the effect of the FTO risk allele on BMI was 30% smaller in physically active individuals (beta = 0.32 kg/m2) than in inactive individuals (beta = 0.46 kg/m2) (Table 2).
