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Chunk #21 — Results — Association of FTO with Obesity Traits (Main Effects)

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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
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In children and adolescents, each FTO risk allele increased age- and sex-specific BMI by 0.10 Z-score units (p = 1×10−21), waist circumference by 0.11 Z-score units (p = 8×10−16), and body fat percentage by 0.12 Z-score units (p = 2×10−11) (Table S3).