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Chunk #20 — Results — Association of FTO with Obesity Traits (Main Effects)

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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
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In adults, each additional risk allele of the FTO rs9939609 variant increased the odds of obesity and overweight by 23% (p = 7×10−59) and 15% (p = 6×10−66), respectively (Table 1). The risk allele also increased BMI by 0.36 kg/m2 (∼1 kg in body weight for a person 170 cm tall) (p = 2×10−75), waist circumference by 0.77 cm (p = 5×10−43), and body fat percentage by 0.30% (p = 2×10−21) (Table 1).