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Chunk #19 — Results — Association of Physical Activity with Obesity Traits (Main Effects)

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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
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Physically active adults had a 33% lower odds of obesity (p = 2×10−13), 19% lower odds of overweight (p = 7×10−9), 0.79 kg/m2 lower BMI (p = 3×10−15), 2.44 cm smaller waist circumference (p = 1×10−20), and 1.30% lower body fat percentage (p = 2×10−15) than inactive adults (Table S1). In children, PA did not have a statistically significant association with age- and sex-standardized BMI (p = 0.2), but physically active children had a waist circumference −0.11 Z-score units smaller (p = 0.04) and a body fat percentage −0.21 Z-score units lower (p = 0.02) than inactive children (Table S2).