negative FHAM or IPA reports were coded as unaffected. All others were coded as missing. Ninety percent of offspring had mothers coded unaffected (56.9%) or affected (33.2%) based on interview (33.0%) or by 2+ FHAM reports (0.2%) . About 2% were possible-AUD, 6.5% were unaffected based on negative FHAM/IPA and 1.6% were missing. Comparable proportions for fathers were unaffected (26.3%) or affected (39.1%) from interview (34.5%) or 2+ FHAM (4.6%), 7.5% possible-AUD, 19.5% unaffected from negative FHAM/IPA, and 7.5% missing. Cross classification of mother's and father's statuses led to 6 dummy variables for analysis: both AUD; fathers AUD mothers not/missing; mother AUD, fathers not/missing; one parent AUD-possible, co-parent unaffected; one unaffected, co-parent missing; with both unaffected as the referent group. Distributions of these variables are presented in Table 1 and Supplemental Table 2.
