GAIN–MDD study,12 replicated in Australian (QIMR)12 and Dutch33 samples, but we found no evidence for association with PCLO variants (for example, P=0.51 for rs2522833), despite partial overlap (562 cases and 264 controls) in the QIMR samples used here and in the original replication sample (see Supplementary File 1 for details). Meta-analysis results of the three largest MDD GWAS—427362 SNPs in MDD2000+, GAIN–MDD and the UK studies—yielded λ1000=1.01 (Figure 1iii). In all, 19 SNPs gave P<5 × 10−5 compared with ∼21 expected under the null hypothesis (ignoring linkage disequilibrium) and are listed in the Supplementary File 1.
