Chunk #20 — DIMENSIONS OF PSYCHOPATHOLOGY IN NEUROLEPTIC-NAÏVE PATIENTS WITH RECENT-ONSET SCHIZOPHRENIA — Corpus callosal area differences in predominantly positive symptom schizophrenia and its implications for temporal dysfunction
The corpus callosum (CC), being the largest mass of connecting white fibers in the brain has evoked much interest among schizophrenia researchers interested in unraveling the underlying connectivity disturbance in schizophrenia. Following the initial report of increased thickness of the CC in postmortem brains of schizophrenia patients by Bigelow and Rosenthal[52] and the subsequent MRI replication of this finding by Nasrallah et al.,[53] the morphometry of CC has been extensively studied in schizophrenia. Shenton et al.,[54] reviewing morphometric studies in schizophrenia, pointed out that among 27 MRI studies of the CC, 17 (63%) reported positive findings while 10 (37%) reported negative findings. The findings across studies have been largely inconsistent, with whole CC areas being reported variously as increased,[5355] decreased,[56] or not different[5758] between schizophrenia subjects and healthy controls.
