Chunk #21 — DIMENSIONS OF PSYCHOPATHOLOGY IN NEUROLEPTIC-NAÏVE PATIENTS WITH RECENT-ONSET SCHIZOPHRENIA — Corpus callosal area differences in predominantly positive symptom schizophrenia and its implications for temporal dysfunction
We studied the CC area in NRS subjects compared to HS, while controlling for several confounders that could affect morphometric measures of the CC such as effects of gender, age, handedness, chronicity of illness, heterogeneity in the symptom profiles, medication status, and the differences in the CC partitioning schemes employed by various researchers. Areas of the whole CC and its sub- regions obtained by two geometric partitioning schemes [Figure 3] were studied in 23 right-handed neuroleptic- naïve, recent- onset, schizophrenia patients and compared with 23 right-handed age-, sex- and education-matched healthy subjects. The patients did not differ from controls in whole CC area. On tripartite division of the CC, the area of the anterior sub-region was significantly higher in patients compared to controls. On radial division into five sub- regions, the anterior truncus area was significantly higher in patients compared to controls. There was a significant effect of gender (F>M) on the area measures; however, there was no significant diagnosis X gender effect. Age, age of onset, duration of illness, and psychopathology ratings did not show any significant correlations with
