Prevailing models of the neuropathology of posttraumatic stress disorder (PTSD) have focused on dysfunctions of the prefrontal-cortex-amygdala circuit (Rauch et al., 2006; Liberzon and Abelson, 2016). Recently, evidence has extended this circuit pathology to implicate large-scale brain network anomalies (Spielberg et al., 2015; Koch et al., 2016; Liberzon and Abelson, 2016; Akiki et al., 2017). Anomalies in the default mode network (DMN), a major resting-state network (RSN), have been especially highlighted in this literature, characterized by attenuated network activity and disrupted network communication (Bluhm et al., 2009; Lanius et al., 2010; Sripada et al., 2012; Koch et al., 2016; Akiki et al., 2018).
