Sixty-one genes across chromosome 2 yielded at least one SNP with P-value <0.001, or at least two SNPs (with an r2 <0.8) with P-values <0.01, and were subjected to permutation testing. Twenty-three genes had an empirical P <0.05. Table II shows the genes that yielded empirical P-values <0.05 in permutation tests. Table II lists the number of SNPs that were tested across each gene, the total number of SNPs that yielded P-values <0.05 across the gene, the number of independent SNPs yielding empirical P-values <0.05, the empirical P-value for the gene based on permutation tests, and the significant SNPs. The original P-values for those SNPs are presented in Supplemental Table I. In Figure 1, the approximate location of these genes is listed along the top of the LOD score graph (based on the microsatellite linkage analyses from the full COGA family sample) to illustrate roughly their chromosomal positions with respect to the linkage peak. Interestingly, none of these genes was located within a 1 LOD drop of the primary, centromeric linkage peak. Rather, those genes in closest proximity to the
