sharing than AD. The allele sharing for AD with CD or SUI was considerably elevated compared to the full AD analysis, and the AD or CD or SUI showed only a very small elevation in allele sharing. Further, the combined phenotype (AD with CD or SUI) showed elevated allele sharing compared to the broader AD or CD or SUI phenotype. This suggests, across both sets of analyses, that the phenotype of AD with CD or SUI represents a more genetically homogeneous subgroup influenced by gene(s) in the region. This was the phenotype used in subsequent association testing.
