Baseline and follow-up data were gathered using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) standardized interview. This instrument has sensitivities and specificities for most diagnoses that range from 75% to 90%, with positive and negative predictive values and retest reliabilities in a similar range (Bucholz et al., 1994; Hesselbrock et al., 1999). Histories of AUDs in a parent were based on interviews with mothers and fathers of these subjects, using imputation for parents who had not been interviewed. Additional details about the prospective study can be found elsewhere (Bucholz et al., 2017).
