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Chunk #13 — RESULTS: — Association analyses

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
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We note that 212 of the 864 lead associations are located within long-range LD regions18 or candidate inversions (i.e., genomic regions that are highly prone to inversion polymorphisms; Supplementary Note). Of these, only 109 are also conditional associations, and 46 are in loci that contain no conditional associations, thus indicating that many lead associations in the long-range LD regions or candidate inversions may tag causal variants that are also tagged by other lead associations. We discuss some of these regions in the next section.