Table 1 lists demographic and alcohol use information by group. The sample consisted of two cohorts, a middle-aged LTAA cohort and their age and gender comparable NAC, and a younger TxN cohort with their age and gender comparable NAC. Both cohorts were recruited using postings at AA meeting sites, mailings, newspaper advertisements, a local Internet site, and subject referrals. The LTAA group was comprised of 24 women and 28 men, ranging from 35 to 58 years of age (mean = 46.6 years), who were abstinent from alcohol and drugs (except nicotine and caffeine) for 6 months to 21 years (mean = 6.3 years). The inclusion criteria for the LTAA group were: 1) met DSM - IV (American Psychiatric Association 2000) criteria for lifetime alcohol dependence, and 2) were abstinent for at least 6 months. A standard drink was defined as 12 oz. beer, 5 oz. wine, or 1.5 oz. liquor. NAC for the LTAA study consisted of 23 women and 25 men, ranging from 34 to 60 years of age (mean = 45.6 years).