In contrast, other SNPs that were reported as genome-wide significant in previous GWAS of MaxDrinks, were not associated with either of our alcohol consumption traits in the current study. Specifically, several SNPs in DDC at 7p12.2 showed significant associations with MaxDrinks in a previous study in a European ancestry population,28 however DDC rs11575537 was not associated in our European ancestry sample with either of our traits. This lack of association at DDC is consistent with prior results of Xu et al. where no significant association with MaxDrinks was observed at this locus.26 In addition, two genome-wide associations for MaxDrinks previously reported in African Americans for ADH1B rs2066702, and rs28864441 at LOC100507053,26 were not associated with alcohol consumption in our African ancestry sample. However, we note that the African American subgroup is the smallest in our study, and we may have been underpowered to detect effects with statistical significance.
