Chunk #51 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.2 Ionotropic Glutamate Receptor Expression Differences (Table 2)

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Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.

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In adult P rats, whereas metabotropic glutamate receptor gene expression levels were consistently lower than those of NP rats; this was not true for Glua and Gluk gene expression,209,211 which was mixed. Glua1, Glua2, Glua3, and Gluk3 expression levels were all lower in the AcbSh of P versus NP rats; whereas Glua4 and Gluk1 expression levels were higher in the AcbSh of P versus NP rats.211 Ethanol-binge drinking by adult P rats reversed the ~30% deficit of Glua1 in the AcbSh through a 15% increase, relative to ethanol-naive controls.208 However, operant ethanol self-administration by adult P rats significantly reduced Glua2 and Glua3 expression levels, versus ethanol-naive controls, in the AcbSh.214 Thus, in spite of AcbSh deficits in Glua2 and Glua3 of adult P versus NP rats,211 operant ethanol self-administration appears to exacerbate this condition with further decreases in expression levels.