Chunk #50 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.2 Ionotropic Glutamate Receptor Expression Differences (Table 2)

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Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.

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Ionotropic glutamate receptor subunits Glua3, Glua4, and Gluk3 were all elevated in the DRN following periadolescent binge-ethanol drinking, but not to the same extent as mGlu1 and mGlu4.213 Gene expression changes were also observed for the “orphan” ionotropic glutamate delta receptor subunits Glud1 and Glud2. Regarding Glud2, there was a 3.5-fold increase in Glud2ip (delphilin) after periadolescent binge drinking as well;213 Glud2ip is a scaffolding protein for Glud2. To some extent, this parallels increases in expression levels of mGlu7, in the CeA, induced by periadolescent binge-ethanol drinking. In the periadolescent binge-drinking P rats, the GluN subunits were generally downregulated, with only the Glun2c subunit being upregulated.213