Chunk #49 — 6. ALCOHOL-ASSOCIATED CHANGES IN GENE/PROTEIN EXPRESSION OF P RATS — 6.1 Metabotropic Glutamate Receptor Expression Differences (Table 1)

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Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.

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Overall, adolescent binge-like ethanol drinking upregulated two of the three mGlu receptors identified as significantly changed. In the AcbSh of adult animals, P rats had only one of the seven mGlu genes identified as significantly greater than that seen in NP rats. It is noteworthy that the one gene that had higher expression levels in the AcbSh of adult P rats was downregulated following ethanol self-administration. Both genes identified as significantly different in the CeA of adult rats were Group II (mGlu2 and mGlu3) metabotropic receptors and were lower in P versus NP rats.