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Chunk #11 — Methods — Measures — Polygenic Risk Scores — Brain Structure.

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Polygenic risk scores for alcohol involvement relate to brain structure in substance-naïve children: Results from the ABCD study.
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Magnetic resonance imaging (MRI) acquisition and processing have been previously described, and are detailed in the Supplement (23,24). We examined regional volume, thickness and surface area of 34 bilateral cortex region in each hemispheres defined in the Desikan-Killany atlas as well as volumes of 12 bilateral subcortical Freesurfer segmentations (25). Fractional anisotropy and mean diffusivity was estimated for 36 white matter tracks defined by AtlasTrack (23). We also evaluated global estimates of each modality (e.g., total cortical thickness).