To determine the joint effect of all 97 BMI loci on other cardiometabolic phenotypes, we used the meta-regression technique from ref. 64 to correlate the effect estimates of the BMI-increasing alleles with effect estimates from meta-analyses for each of the metabolic traits from other consortia (DIAGRAM, MAGIC, ICBP, GLGC, ADIPOGen, ReproGen and CARDIoGRAM).
