There are several strengths of this study, including a relatively large sample size and use of the genome-wide polygenic score approach to characterize genetic risk. In addition, we included a sample of both EAs and AAs and our findings contribute to the limited G×E literature among non-European populations (Dick et al., 2017). Furthermore, our sample of a wide age range allowed for the examination of differences in the role of alc-PRS and social support in relation to alcohol use across emerging, young, and middle adulthood. Despite these strengths, our findings need to be interpreted in light of several limitations. First, our cross-sectional analyses preclude us from making causal inferences regarding the relation between social support and alcohol use. Second, our examination of differences across developmental periods based on these cross-sectional analyses may also be subject to bias due to cohort effects. Future research should employ longitudinal designs to examine within-person changes in the role of genetic risk and social support in relation to alcohol use across development. Third, despite using a relatively large sample size compared to many other prior
