Overexpression of LINC00665 in glioma cells resulted in downregulated expression of the transcription factor YY2. Furthermore, when STAU1 was knocked down in U87 and U251 glioma cells, YY2 expression was upregulated compared with that in the STAU1− NC group. Moreover, LINC00665 overexpression combined with STAU1 inhibition could rescue the reduction in MTF1 mRNA and protein expression levels compared with that in the LINC00665+ group (Figures 4F and 4G).
