A further eight SNPs are located within genes: rs13362120 (combined p-value 1.85×10-5) in the calpastatin (CAST) gene; rs13160562 (combined p-value 7.09×10-6) in the endoplasmatic reticulum aminopeptidase 1 (ERAP1)/calpastatin (CAST) genes; rs1864982 (combined p-value 3.46×10-6) in the protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform (PPP2R2B)gene; rs6902771 (combined p-value 8.30×10-6) in the estrogen receptor 1 (ESR1) gene; rs7138291 (combined p-value 3.68×10-5) in the coiled-coil domain containing 41 (CCDC41) gene; rs1614972 (combined p-value 1.41×10-4) in the alcohol dehydrogenase 1c (ADH1C) gene; rs13273672 (combined p-value 4.75×10-4) located in the GATA binding protein 4 (GATA4) gene and rs11640875 (combined p-value 1.84×10-5) in the cadherin 13 (CDH13) gene. The first five SNPs were selected for the follow-up study through the ‘lowest p-value’ strategy and the latter three via the ‘rodent candidate gene’ approach. These findings and those of the intergenic SNPs are provided in Table 1, Table 2 and eTable 5.
